Matrix & Growth-Factor Peptides
KPV — 10mg
$54
This product is intended for research purposes only. Not intended for human or animal consumption. Not intended to diagnose, treat, cure, or prevent any disease. By purchasing, you acknowledge that you are a qualified researcher and understand the nature of this product.
KPV is the C-terminal tripeptide fragment (Lys-Pro-Val) of alpha-melanocyte-stimulating hormone, a 13-residue peptide hormone; it is supplied as a lyophilized powder in a 10 mg vial.
Matrix & Growth-Factor PeptidesOverview
KPV (Lys-Pro-Val) is a three-residue peptide corresponding to residues 11-13 of alpha-melanocyte-stimulating hormone. The central proline restricts backbone conformation and contributes to resistance against peptidase cleavage. It is supplied as a lyophilized white powder.
In cultured epithelial cells the tripeptide enters through the PepT1 di- and tripeptide transporter and attenuates NF-kB nuclear translocation, with correspondingly lower transcript levels of TNF-alpha, interleukin-1 beta, and interleukin-6. Activity in these assays occurs independently of melanocortin receptor binding. Each vial contains 10 mg.
Mechanism of Action
Enters cultured epithelial cells via the PepT1 di- and tripeptide transporter and attenuates NF-kB nuclear translocation, lowering transcript levels of TNF-alpha, interleukin-1 beta, and interleukin-6 independently of melanocortin receptors.
Certificates of Analysis1
Independent third-party lab reports for this peptide. Each CoA can be verified against its accession number at the testing lab.
1 independent test by Freedom Diagnostics Testing
| Test | Result |
|---|---|
| Purity (HPLC) | 99.934% |
| Identity (MS) | Pass |
| Endotoxins (LAL) | Pass |
Lab: Freedom Diagnostics Testing
Accession: 2601120036 / 2601120037
Reports are verifiable against the issuing lab using the accession or batch identifier above.
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