Neuropeptides
Melanotan-II — 8mg
$33
This product is intended for research purposes only. Not intended for human or animal consumption. Not intended to diagnose, treat, cure, or prevent any disease. By purchasing, you acknowledge that you are a qualified researcher and understand the nature of this product.
Melanotan-II is a synthetic cyclic heptapeptide analogue of alpha-melanocyte-stimulating hormone, closed by an Asp-Lys lactam bridge and acting as an agonist across the MC1R through MC5R receptor family.
NeuropeptidesOverview
Melanotan-II is a synthetic cyclic heptapeptide analogue of alpha-melanocyte-stimulating hormone with the structure Ac-Nle-cyclo(Asp-His-D-Phe-Arg-Trp-Lys)-NH2. An amide bond between the aspartate and lysine side chains forms a lactam bridge that constrains the ring conformation and gives the molecule resistance to enzymatic degradation. It is the structural parent of bremelanotide.
In vitro the peptide is a non-selective agonist at melanocortin receptors MC1R, MC3R, MC4R, and MC5R, each a Gs-coupled receptor coupling to adenylate cyclase and cyclic AMP. Melanotan-II is supplied as a lyophilized powder in an 8 mg vial.
Mechanism of Action
Melanotan-II is a non-selective agonist at melanocortin receptors MC1R through MC5R; its lactam-constrained ring conformation is associated with high measured binding affinity at each Gs-coupled subtype in vitro.
Certificates of Analysis1
Independent third-party lab reports for this peptide. Each CoA can be verified against its accession number at the testing lab.
1 independent test by Freedom Diagnostics Testing
| Test | Result |
|---|---|
| Purity (HPLC) | 99.868% |
| Identity (MS) | Pass |
| Endotoxins (LAL) | Pass |
Lab: Freedom Diagnostics Testing
Accession: 2603130087 / 2603130088
Reports are verifiable against the issuing lab using the accession or batch identifier above.
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