Immune & Cellular Peptides
PNC-27 — 5mg
$95
This product is intended for research purposes only. Not intended for human or animal consumption. Not intended to diagnose, treat, cure, or prevent any disease. By purchasing, you acknowledge that you are a qualified researcher and understand the nature of this product.
PNC-27 is a synthetic 32-residue chimeric peptide in which a segment corresponding to residues 12-26 of p53 is fused to a cationic, penetratin-class membrane-residency sequence, supplied as 5mg of lyophilized powder.
Immune & Cellular PeptidesOverview
PNC-27 is assembled from two segments. The N-terminal segment reproduces residues 12-26 of the p53 transactivation domain, the region that forms the contact surface with HDM-2. The C-terminal segment is a cationic, tryptophan- and arginine-rich sequence of the penetratin class, which gives the construct affinity for lipid bilayers.
The construct carries a net positive charge at neutral pH. Published molecular characterization originates from a small and closely related set of research groups; no independent replication was identified, and the compound holds no approved status in any jurisdiction. It is supplied strictly as a laboratory reagent.
Mechanism of Action
The p53-derived segment corresponds to the region of p53 that contacts HDM-2; the cationic penetratin-class segment associates with lipid bilayers in vitro. No further mechanism is claimed for this reagent.
Certificates of Analysis1
Independent third-party lab reports for this peptide. Each CoA can be verified against its accession number at the testing lab.
1 independent test by Freedom Diagnostics Testing
| Test | Result |
|---|---|
| Purity (HPLC) | 99.62% |
| Identity (MS) | Pass |
| Endotoxins (LAL) | Pass |
Lab: Freedom Diagnostics Testing
Accession: 2607270373
Reports are verifiable against the issuing lab using the accession or batch identifier above.
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